Extracellular phospholipase A2 activity in cell free peritoneal lavage fluid from mice with zymosan peritonitis

The kinetics and appearance of extracellular phospholipase A2 (PLA2) activity and its relationship to the appearance of arachidonic acid (AA) metabolites in the peritoneal cavity of mice injected with zymosan is described. AA metabolites levels including leukotriene C4 (LTC4) were maximum 15-30 min...

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Bibliographic Details
Published inAgents and actions Vol. 27; no. 3-4; p. 341
Main Authors Gans, K R, Lundy, S R, Dowling, R L, Stevens, T M, Kerr, J S
Format Journal Article
LanguageEnglish
Published Switzerland 01.06.1989
Subjects
Animals
Arachidonic Acid
Arachidonic Acids - metabolism
Male
Mice
Peritonitis - chemically induced
Peritonitis - immunology
Peritonitis - metabolism
Phospholipases - metabolism
Phospholipases A - metabolism
Phospholipases A2
SRS-A - metabolism
Therapeutic Irrigation
Time Factors
Zymosan
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Summary:The kinetics and appearance of extracellular phospholipase A2 (PLA2) activity and its relationship to the appearance of arachidonic acid (AA) metabolites in the peritoneal cavity of mice injected with zymosan is described. AA metabolites levels including leukotriene C4 (LTC4) were maximum 15-30 min after zymosan. Peak PLA2 activity was also found 15-30 min after zymosan and was significantly increased above levels found in saline control exudates (3.83 +/- 0.89 and 0.35 +/- 0.11, respectively, p less than or equal to 0.05). Results show that an extracellular PLA2 is present in zymosan peritonitis.
ISSN:0065-4299
DOI:10.1007/BF01972817