Sex as a main determinant of bi-atrial acute and chronic adaptation to exercise

• Published in: European journal of applied physiology Vol. 122; no. 12; pp. 2585 - 2596
• Main Authors: Simard, Francois, Sanz-de la Garza, María, Vaquer-Seguí, Antonia, Blanco, Isabel, Burgos, Felip, Alsina, Xavier, Prat-González, Susanna, Sitges, Marta
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Adaptation; Biomedical and Life Sciences; Biomedicine; Gender differences; Human Physiology; Muscle contraction; Occupational Medicine/Industrial Medicine; Original Article; Sex differences; Sports Medicine; Women; Athlete’s heart; Women’s health; Atrial strain; Atrial dilatation
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-022-05018-x

Purpose Athlete’s heart encompasses multiple physiological cardiac adaptations, although less is known at atrial level. How sex may influence the type and extent of atrial adaptations to exercise stimuli is also unknown. Our objective was to compare gender differences of echocardiographic atrial function indices in response to exercise in endurance athletes (EAs). Methods Highly trained (> 10 h/week) endurance athletes performed a maximal cardiopulmonary exercise test (CPET). Echocardiographic evaluation was performed at rest and immediately after exercise. Atria analysis consisted of standard and speckle-tracking echocardiographic assessment of atrial dimensions and contractile, reservoir, and conduit functions with myocardial deformation. Results 80 EAs (55% women) were enrolled and performed excellent CPET (129.6% of predicted VO 2 maximal consumption). At rest, left atrial (LA) volumes and strain were similar between men and women. Women had lower right atrial (RA) volumes (26.7 vs 32.9 ml/m 2 , p  < 0.001) and higher reservoir and conduit strain absolute values. After exercise, women exhibited a larger improvement in reservoir and conduit LA strain, and the same trend was observed for the RA. In EAs with LA dilatation on baseline (~ 50%), women persistently showed higher increase in reservoir and conduit strain profile with exercise compared to men. Conclusion In highly trained EAs, women have similar or even lower atrial dimensions remodelling compared to men, but better function based on reservoir and conduit strain values both at rest and in response to exercise. This phenomenon should be confirmed in larger studies and its potential role in the development of supraventricular arrhythmias, addressed in a specifically designed protocol.