A high-resolution genetic map of mouse chromosome 15 encompassing the Dominant megacolon (Dom) locus

Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with hig...

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Bibliographic Details
Published inMammalian genome Vol. 6; no. 11; p. 763
Main Authors Puliti, A, Prehu, M O, Simon-Chazottes, D, Ferkdadji, L, Peuchmaur, M, Goossens, M, Guénet, J L
Format Journal Article
LanguageEnglish
Published United States 01.11.1995
Subjects
Animals
Chromosome Mapping - methods
Crosses, Genetic
Female
Hirschsprung Disease - genetics
Male
Mice
Mice, Mutant Strains
Microsatellite Repeats
Mutation
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Summary:Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra-and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.
ISSN:0938-8990
DOI:10.1007/BF00539000