Severe microvascular disease in type II diabetes of early onset. A family study

Both early onset and late onset type II diabetes were present in one family of nine siblings. The three early onset type II diabetic siblings showed severe microvascular complications: proliferative retinopathy, diabetic nephropathy, and peripheral neuropathy. Early onset type II diabetes was not as...

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Bibliographic Details
Published inActa diabetologica latina Vol. 26; no. 1; p. 58
Main Authors Scalvini, T, Spandrio, S, di Stefano, O, Cotelli, M C, Carella, G, Balestrieri, G P
Format Journal Article
LanguageEnglish
Published Italy 01.01.1989
Subjects
Adult
C-Peptide - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Diabetic Angiopathies - blood
Diabetic Angiopathies - genetics
Female
Humans
Male
Middle Aged
Pedigree
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Summary:Both early onset and late onset type II diabetes were present in one family of nine siblings. The three early onset type II diabetic siblings showed severe microvascular complications: proliferative retinopathy, diabetic nephropathy, and peripheral neuropathy. Early onset type II diabetes was not associated with any particular HLA haplotype. Early onset type II diabetes could be considered a clinical and genetic disease entity different from MODY type diabetes.
ISSN:0001-5563
DOI:10.1007/BF02581198