Fatal nitrosamine poisoning

A case is reported in which progressive liver symptoms with rise in bilirubin concentration, hemorrhagic diathesis, and signs of portal hypertension developed three years before death in liver coma. The pathologic and neuropathologic findings are described. The case was clarified after dimethylnitro...

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Published inArchives of toxicology Vol. 50; no. 2; p. 101
Main Authors Pedal, I, Besserer, K, Goerttler, K, Heymer, B, Mittmeyer, H J, Oehmichen, M, Schmähl, D
Format Journal Article
LanguageEnglish
Published Germany 01.07.1982
Subjects
Adult
Chemical and Drug Induced Liver Injury - chemically induced
Chemical and Drug Induced Liver Injury - pathology
Dimethylnitrosamine - poisoning
Female
Food Analysis
Humans
Liver - pathology
Liver Cirrhosis - chemically induced
Liver Cirrhosis - pathology
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Summary:A case is reported in which progressive liver symptoms with rise in bilirubin concentration, hemorrhagic diathesis, and signs of portal hypertension developed three years before death in liver coma. The pathologic and neuropathologic findings are described. The case was clarified after dimethylnitrosamine was demonstrated in food intended for the patient and after it was established that small amounts of nitrosamine could have been repeatedly ingested by the patient over a period of years. Comparable cases of human dimethylnitrosamine poisonings published in the literature are presented. The relatively typical morphologic alterations in the liver are described. Problems involved in the histological interpretation of such liver changes as well as the forensic conclusions to be drawn are discussed.
ISSN:0340-5761
DOI:10.1007/BF00373392