First Case of Atypical, Generalized Skin Rash after Transarterial Chemoembolization in a Patient with Hepatocellular Carcinoma

Transarterial chemoembolization (TACE) is a widely used hepatocellular carcinoma (HCC) treatment. Some cases of supraumbilical skin rash after TACE in patients with HCC have been reported. To the best of the authors' knowledge, there are no reports on atypical, generalized rashes caused by doxo...

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Published inThe Korean journal of gastroenterology Vol. 81; no. 4; pp. 173 - 177
Main Authors Lee, Yohan, Cho, Eunae, Park, Chang Hwan, Yoon, Jae Hyun, Choi, Sung Kyu, Kim, Hyoung Ook, Park, Chan, Yun, Sook Jung
Format Journal Article
LanguageEnglish
Published Korea (South) Jin Publishing & Printing Co 25.04.2023
Subjects
carcinoma
Carcinoma, Hepatocellular - pathology
Chemoembolization, Therapeutic - adverse effects
Doxorubicin - therapeutic use
drug-related side effects and adverse reactions
exanthema
Exanthema - etiology
Exanthema - therapy
hepatocellular
Humans
Liver Neoplasms - pathology
Male
Middle Aged
Retrospective Studies
Treatment Outcome
therapeutic
Carcinoma
Drug-related side effects and adverse reactions
Exanthema
Chemoembolization
hepatocellular
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Summary:Transarterial chemoembolization (TACE) is a widely used hepatocellular carcinoma (HCC) treatment. Some cases of supraumbilical skin rash after TACE in patients with HCC have been reported. To the best of the authors' knowledge, there are no reports on atypical, generalized rashes caused by doxorubicin systemic absorption after TACE. This paper presents the case of a 64-year-old male with HCC who developed generalized macules and patches one day after a successful TACE procedure. A histology examination of a skin biopsy of a dark reddish patch on the knee revealed severe interface dermatitis. He was treated with a topical steroid, and all skin rashes improved within a week with no side effects. This report presents this rare case with a literature review on skin rash after TACE.
ISSN:1598-9992
2233-6869
DOI:10.4166/kjg.2023.030