Cell division, chromosomal aberration, and micronuclei formation in human peripheral blood lymphocytes. Effect of stannic chloride on donor's age

Age related cytotoxicity of stannic chloride was evaluated in human lymphocytes considering mitotic index (MI), damaged cell (DC), chromosome aberration (CA), and micronuclei formation (MNC) as endpoints. Significant elevation of DCs, CAs, MNCs, and reduction of MI were observed in all classified ag...

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Bibliographic Details
Published inBiological trace element research Vol. 38; no. 1; p. 55
Main Author Ganguly, B B
Format Journal Article
LanguageEnglish
Published United States 01.07.1993
Subjects
Adolescent
Adult
Age Factors
Aged
Cell Division - drug effects
Child
Chromosome Aberrations
Female
Humans
In Vitro Techniques
Lymphocytes - drug effects
Lymphocytes - ultrastructure
Male
Micronucleus Tests
Middle Aged
Mitotic Index - drug effects
Tin Compounds - toxicity
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Summary:Age related cytotoxicity of stannic chloride was evaluated in human lymphocytes considering mitotic index (MI), damaged cell (DC), chromosome aberration (CA), and micronuclei formation (MNC) as endpoints. Significant elevation of DCs, CAs, MNCs, and reduction of MI were observed in all classified age groups compared to each control set. The mean frequencies of abnormalities show a statistically significant increase with subject's age. Linearity of the effect of age was common for both untreated and treated lymphocytes of both sexes.
ISSN:0163-4984
DOI:10.1007/BF02783982