Association Between Chronic Obstructive Pulmonary Disease and Mortality in Participants with Arthritis: Data from the National Health and Nutrition Examination Survey 1999–2018

Chronic obstructive pulmonary disease (COPD) is closely associated with arthritis. This study aims to evaluate the correlation between COPD and mortality among participants with arthritis. The study included 11,298 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-...

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Published inChronic obstructive pulmonary diseases Vol. 12; no. 1; pp. 61 - 71
Main Authors Zhang, Yingying, Chen, Guangxi, Huang, Aixia, Hu, Ying, Fu, Chengfeng
Format Journal Article
LanguageEnglish
Published United States COPD Foundation Inc 29.01.2025
Subjects
Origianl Research
NHANES
arthritis
all-cause mortality
COPD
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Summary:Chronic obstructive pulmonary disease (COPD) is closely associated with arthritis. This study aims to evaluate the correlation between COPD and mortality among participants with arthritis. The study included 11,298 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, who self-reported having arthritis. Cox proportional hazard models were used to assess the association between COPD and mortality among participants with arthritis. Kaplan-Meier survival curves were plotted to compare survival probabilities between groups. Subgroup and sensitivity analyses were conducted to assess the robustness of the results. During an average follow-up of 8.8 years, 3061 all-cause deaths were observed, including 1024 related to cardiovascular disease (CVD). After weighted multivariable adjustment, COPD was found to be significantly associated with both all-cause and CVD mortality among these arthritis participants. The hazard ratio (HR) for all-cause mortality among arthritis patients with COPD was 1.41 (95% confidence interval [CI]: 1.25-1.60, < 0.001), and the HR for CVD mortality was 1.29 (95% CI: 1.08-1.53, < 0.001). Kaplan-Meier survival curves attributed higher rates of both all-cause and CVD mortality among participants with COPD compared to those without (log-rank test, < 0.001). Additionally, COPD increased the risk of both chronic lower respiratory disease (CLRD) mortality (HR 5.46, 95% CI: 3.48-8.56, < 0.001) and non-CLRD mortality (HR 1.24, 95% CI: 1.07-1.44, =0.004). In the American population, arthritis patients with COPD have higher risks of all-cause and CVD mortality compared to those without COPD.
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Data sharing statement: Data of publicly available datasets was analyzed in this study. All data are available on the NHANES website (https://www.cdc.gov/nchs/nhanes/).
Author contributions: YZ was responsible for data curation, formal analysis, investigation, project administration, visualization, funding acquisition, and writing the original draft of the manuscript. GC was responsible for data curation, investigation, project administration, and writing the original draft of the manuscript. AH was responsible for visualization, data curation, and writing the original draft of the manuscript. YH was responsible for conceptualization, methodology, supervision, validation, and writing, reviewing, and editing the manuscript. CF was responsible for conceptualization, methodology, project administration, data curation, resources, supervision, validation, and writing, reviewing, and editing the manuscript. All authors agreed to submit the article to this journal and agreed to be accountable for all aspects of the work.
The authors declare no competing interests.
Other acknowledgments: The authors express their sincere thanks to those who developed and maintain the database, and to the clinical scientist team for their ongoing support and insightful guidance.
ISSN:2372-952X
2372-952X
DOI:10.15326/jcopdf.2024.0573