Experimental evaluation of peritoneum and pericardium as dural substitutes

Although many substances have been tested in the search for an ideal dural substitute, an entirely satisfactory material has still not been found. The authors report an experimental study involving the closure of dural defects in rabbits with biomaterials developed from pig peritoneum and pericardiu...

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Bibliographic Details
Published inResearch in experimental medicine Vol. 195; no. 1; p. 31
Main Authors Gök, A, Zorludemir, S, Polat, S, Tap, O, Kaya, M
Format Journal Article
LanguageEnglish
Published Germany 01.12.1995
Subjects
Animals
Biocompatible Materials
Cell Adhesion - physiology
Cerebral Cortex - cytology
Dura Mater - transplantation
Graft Survival - physiology
Microscopy, Electron
Pericardium - cytology
Pericardium - transplantation
Peritoneum - cytology
Peritoneum - transplantation
Rabbits
Swine
Wound Healing - physiology
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Summary:Although many substances have been tested in the search for an ideal dural substitute, an entirely satisfactory material has still not been found. The authors report an experimental study involving the closure of dural defects in rabbits with biomaterials developed from pig peritoneum and pericardium. Macroscopic and histologic examination, performed over a period between 15 and 45 days after implantation showed slight or no adhesion between the graft material and the cortex. No infection, CSF leakage, fistula or toxicity was noticed. The results demonstrated that these biomaterials could be used as satisfactory dural substitutes.
ISSN:0300-9130
DOI:10.1007/BF02576771