Treatment of chronic replicative hepatitis B virus infection with short-term continuous infusion of foscarnet

Three patients with chronic replicative hepatitis B virus infection were treated for 7 days with a continuous intravenous infusion of foscarnet (trisodium phosphonoformate) after an initial bolus dose of 20 mg/kg body weight. Although the dose was calculated from a nomogram, approximately only half...

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Bibliographic Details
Published inInfection Vol. 22; no. 5; p. 330
Main Authors Schvarcz, R, Hansson, B G, Lernestedt, J O, Weiland, O
Format Journal Article
LanguageEnglish
Published Germany 01.09.1994
Subjects
Adult
Chronic Disease
DNA, Viral - blood
Follow-Up Studies
Foscarnet - administration & dosage
Foscarnet - blood
Foscarnet - therapeutic use
Hepatitis B - blood
Hepatitis B - drug therapy
Humans
Infusions, Intravenous
Male
Middle Aged
Polymerase Chain Reaction
Treatment Outcome
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Summary:Three patients with chronic replicative hepatitis B virus infection were treated for 7 days with a continuous intravenous infusion of foscarnet (trisodium phosphonoformate) after an initial bolus dose of 20 mg/kg body weight. Although the dose was calculated from a nomogram, approximately only half the intended plasma concentration (500 microM/l = 150 micrograms/l) was achieved. The levels of s-ALAT, HBV-DNA and DNA-polymerase changed only marginally during the treatment and 24-week follow-up period. All three patients remained HBsAg and HBeAg positive during treatment and follow-up. There were no severe side-effects. We conclude that foscarnet treatment with the dose regimen given in this study had no or only a minor antiviral effect in patients with chronic replicative HBV infection. It remains to be explored if higher doses, longer treatment periods or the use of foscarnet in combination regimen are more effective.
ISSN:0300-8126
DOI:10.1007/BF01715540