Amplification of the bradykinin response in rat uterus by pCMB-Dextran T 10

pCMB-Dextran T 10,a large, non-penetrating SH-blocking reagent caused a reversible amplification of bradykinin sensituvity in the isolated rat uterus. High concentrations of this compound (1 x 10-3 M) can evoke spontaneous uterus contraction. pCMB-Dextran T 10 did not alter the biological activity o...

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Bibliographic Details
Published inAgents and actions Vol. 5; no. 3; p. 236
Main Authors Mann, K, Bachhuber, F, Kather, H, Simon, B
Format Journal Article
LanguageEnglish
Published Switzerland 01.08.1975
Subjects
Animals
Bradykinin - pharmacology
Chloromercuribenzoates - pharmacology
Dextrans - analogs & derivatives
Dextrans - pharmacology
Drug Synergism
Female
In Vitro Techniques
Rats
Sulfhydryl Reagents - pharmacology
Uterine Contraction - drug effects
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Summary:pCMB-Dextran T 10,a large, non-penetrating SH-blocking reagent caused a reversible amplification of bradykinin sensituvity in the isolated rat uterus. High concentrations of this compound (1 x 10-3 M) can evoke spontaneous uterus contraction. pCMB-Dextran T 10 did not alter the biological activity of bradykinin. It is assumed that superficial membrane SH-groups are involved in the uterus contraction mechanism.
ISSN:0065-4299
DOI:10.1007/BF02026437