Cystathionase: a potential cytoplasmic marker of hematopoietic differentiation

• Published in: Blut Vol. 47; no. 1; p. 31
• Main Authors: Link, D, Drebing, C, Glode, L M
• Format: Journal Article
• Language: English
• Published: Germany 01.07.1983
• Subjects: Bone Marrow Cells; Cell Differentiation; Cell Line; Colony-Forming Units Assay; Cystathionine - metabolism; Cystathionine gamma-Lyase - metabolism; Cysteine - metabolism; Cytoplasm - enzymology; Hematopoietic Stem Cells - enzymology; Humans; Leukemia - enzymology; Lyases - metabolism

Cysteine auxotrophy and absence of cystathionase (CSE) has been associated with certain human and rodent leukemic cell lines. To determine whether this state was a marker of malignant transformation or of cellular differentiation, CSE content was measured in 16 well characterized human leukemia-lymp...