Radioiodinated fatty acid esters in the management of hepatocellular carcinoma: preliminary findings

Radioiodinated fatty acid esters, such as lipiodol or ethiodol, are localized in the hypervascular hepatocellular carcinoma (HCC) for a long time following intra-arterial hepatic injection, enabling delivery of high internal radiation to the tumor. The desired radiation can easily be delivered to sm...

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Bibliographic Details
Published inCancer chemotherapy and pharmacology Vol. 23 Suppl; p. S54
Main Authors Yoo, H S, Park, C H, Suh, J H, Lee, J T, Kim, D I, Kim, B S, Madsen, M T
Format Journal Article
LanguageEnglish
Published Germany 1989
Subjects
Adult
Aged
Carcinoma, Hepatocellular - radiotherapy
Embolization, Therapeutic
Female
Humans
Iodine Radioisotopes - therapeutic use
Iodized Oil - administration & dosage
Liver Neoplasms - radiotherapy
Male
Middle Aged
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Summary:Radioiodinated fatty acid esters, such as lipiodol or ethiodol, are localized in the hypervascular hepatocellular carcinoma (HCC) for a long time following intra-arterial hepatic injection, enabling delivery of high internal radiation to the tumor. The desired radiation can easily be delivered to small HCC, less than 5 cm in diameter, in single or multiple procedures with an 8-week interval. For larger tumors, [131I]lipiodol or [131I]ethiodol in conjunction with chemotherapy emulsion, Ivalon embolization or all three combinations should be considered for maximal clinical results. A strong beta emitter with shorter physical half-life, i.e. 90Y will be more effective in the management of HCC if one can label lipiodol with 90Y.
ISSN:0344-5704
DOI:10.1007/BF00647241