Okichromanone, a new antiviral chromanone from a marine-derived Microbispora

Okichromanone (1), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora, along with known 1-hydroxyphenazine (2). Compound 1 was elucidated to exist as a mixture of two isomeric structures (1a and 1b) at a ratio of nearly 3:2. Compounds 1 and 2 showed...

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Published inJournal of antibiotics Vol. 77; no. 6; pp. 389 - 392
Main Authors Elsbaey, Marwa, Jomori, Takahiro, Tanaka, Junichi, Oku, Naoya, Igarashi, Yasuhiro
Format Journal Article
LanguageEnglish
Published LONDON Springer Nature 01.06.2024
Nature Publishing Group
Subjects
Actinobacteria - chemistry
Animals
Antibiotics
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Biotechnology & Applied Microbiology
Carbon
Chlorocebus aethiops
Chromones - chemistry
Chromones - isolation & purification
Chromones - pharmacology
Herpesvirus 1, Human - drug effects
Immunology
Inhibitory Concentration 50
Life Sciences & Biomedicine
Metabolites
Microbiology
Molecular Structure
Pharmacology & Pharmacy
Porifera - chemistry
Science & Technology
Vero Cells
CHROMONE
GENUS MICROBISPORA
SP NOV
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Summary:Okichromanone (1), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora, along with known 1-hydroxyphenazine (2). Compound 1 was elucidated to exist as a mixture of two isomeric structures (1a and 1b) at a ratio of nearly 3:2. Compounds 1 and 2 showed anti HSV-I activity with IC50 values 40 and 86 mu M, respectively, and anti HSV-II activity with IC50 values 59 and 123 mu M, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-024-00718-2