Lack of lipid involvement in nonosseous tissue repair

• Published in: Proceedings of the Society for Experimental Biology and Medicine Vol. 174; no. 1; p. 59
• Main Authors: Timchak, D M, Boskey, A L, Vigorita, V
• Format: Journal Article
• Language: English
• Published: United States 01.10.1983
• Subjects: Animals; Calcium - analysis; Female; Lipids - physiology; Male; Phosphates - analysis; Phospholipids - analysis; Rats; Rats, Inbred Strains; Skin Physiological Phenomena; Wound Healing
• DOI: 10.3181/00379727-174-41704
• ISSN: 0037-9727

Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) have been implicated in the onset of tissue mineralization in healing fracture callus as well as in normal osteogenesis. Although these complexes are not found in nonmineralizing normal tissues, the possibility that they are more involved in healing phenomena than in actual mineralization cannot be excluded. The present study confirms that Ca-PL-PO4 complexes are only involved with osseous repair. In healing skin at 5, 8, and 11 days after wounding, Ca-PL-PO4 concentration was not significantly elevated (percentage complexed lipid P/total lipid P: 3.7, 2.4, and 3.8, respectively) relative to the value found for normal skin (2 +/- 2%), although the total lipid phosphorus content at 8 and 11 days was increased.