Lack of lipid involvement in nonosseous tissue repair

Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) have been implicated in the onset of tissue mineralization in healing fracture callus as well as in normal osteogenesis. Although these complexes are not found in nonmineralizing normal tissues, the possibility that they are more involved i...

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Bibliographic Details
Published inProceedings of the Society for Experimental Biology and Medicine Vol. 174; no. 1; p. 59
Main Authors Timchak, D M, Boskey, A L, Vigorita, V
Format Journal Article
LanguageEnglish
Published United States 01.10.1983
Subjects
Animals
Calcium - analysis
Female
Lipids - physiology
Male
Phosphates - analysis
Phospholipids - analysis
Rats
Rats, Inbred Strains
Skin Physiological Phenomena
Wound Healing
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Summary:Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) have been implicated in the onset of tissue mineralization in healing fracture callus as well as in normal osteogenesis. Although these complexes are not found in nonmineralizing normal tissues, the possibility that they are more involved in healing phenomena than in actual mineralization cannot be excluded. The present study confirms that Ca-PL-PO4 complexes are only involved with osseous repair. In healing skin at 5, 8, and 11 days after wounding, Ca-PL-PO4 concentration was not significantly elevated (percentage complexed lipid P/total lipid P: 3.7, 2.4, and 3.8, respectively) relative to the value found for normal skin (2 +/- 2%), although the total lipid phosphorus content at 8 and 11 days was increased.
ISSN:0037-9727
DOI:10.3181/00379727-174-41704