Risk factors of the cutaneous melanoma phenotype

Of 20 melanoma patients 85% show a prolonged erythema persistence after a marked test erythema of 8 MED with 300 nm +/- 10 nm (control group only 34%). This phenomenon does not correlate with the skin type and is useful in identifying high-risk patients prone to melanoma and light-induced skin cance...

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Bibliographic Details
Published inArchives of dermatological research Vol. 270; no. 1; p. 33
Main Authors Jung, E G, Günthart, K, Metzger, R F, Bohnert, E
Format Journal Article
LanguageEnglish
Published Germany 01.01.1981
Subjects
Adult
Aged
Erythema - genetics
Female
Humans
Male
Melanoma - genetics
Middle Aged
Phenotype
Risk
Sister Chromatid Exchange
Skin Neoplasms - genetics
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Summary:Of 20 melanoma patients 85% show a prolonged erythema persistence after a marked test erythema of 8 MED with 300 nm +/- 10 nm (control group only 34%). This phenomenon does not correlate with the skin type and is useful in identifying high-risk patients prone to melanoma and light-induced skin cancer (92%). The spontaneous and the UV-C-induced number of sister chromatid exchanges (SCE) per metaphase was significantly higher in peripheral leukocytes of melanoma patients than in normal controls. The attempt was made to establish a "risk-spectrum" of cutaneous melanoma phenotype.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00417147