The effect of fluoride alone or fluoride followed by calcium and vitamin D on disuse osteoporosis of the rat tail vertebrae

The therapeutic effect of fluoride alone or fluoride followed by calcium and vitamin D administration on the osteoporosis induced by immobilization of the rat tail vertebrae was investigated. Tail immobilization was carried out by musclectomy and tendectomy. After 60 days of immobilization, the vert...

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Bibliographic Details
Published inCalcified tissue research Vol. 19; no. 1; p. 9
Main Authors Rosen, D, Gedalia, I, Anaise, J, Simkin, A, Arcan, M
Format Journal Article
LanguageEnglish
Published Germany 01.12.1975
Subjects
Animals
Bone and Bones - analysis
Calcium - analysis
Calcium - therapeutic use
Drug Therapy, Combination
Ergocalciferols - therapeutic use
Fluorides - analysis
Fluorides - therapeutic use
Immobilization
Male
Osteoporosis - drug therapy
Osteoporosis - metabolism
Phosphorus - analysis
Rats
Stress, Mechanical
Tail
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Summary:The therapeutic effect of fluoride alone or fluoride followed by calcium and vitamin D administration on the osteoporosis induced by immobilization of the rat tail vertebrae was investigated. Tail immobilization was carried out by musclectomy and tendectomy. After 60 days of immobilization, the vertebrae were examined for bone mass, breaking strength, ash percentage and Ca, P and F content. NaF or Ca and vitamin D as separate treatments improved the osteoporosis induced by immobilization. The effects of NaF treatment were more pronounced than those of Ca and vitamin D. NaF and NaF followed by Ca and vitamin D produced a similar degree of improvement in breaking strength. The fact that fluoride and calcium and vitamin D were administered separately and sequentially may explain the absence of a synergistic effect.
ISSN:0008-0594
DOI:10.1007/BF02563986