Bacteria and their products peptidoglycan and teichoic acid potentiate antigen-induced histamine release in allergic patients

Histamine release was examined in leukocyte suspensions from patients allergic to grass pollen, mite or cat dander or to bacteria (antigen). When the cells were challenged with specific antigen plus bacteria to which the person was not sensitized, these bacteria were found to potentiate the allergic...

Full description

Saved in:
Bibliographic Details
Published inAgents and actions Vol. 20; no. 3-4; p. 174
Main Authors Norn, S, Jarløv, J O, Jensen, C B, Clementsen, P, Dahl, B T, Espersen, F, Stahl Skov, P
Format Journal Article
LanguageEnglish
Published Switzerland 01.04.1987
Subjects
Antigens, Bacterial - immunology
Asthma - physiopathology
Histamine Release
Humans
Hypersensitivity - physiopathology
In Vitro Techniques
Leukocytes - immunology
Leukocytes - metabolism
Peptidoglycan
Rhinitis, Allergic, Seasonal - physiopathology
Staphylococcus aureus - immunology
Streptococcus pneumoniae - immunology
Teichoic Acids
Online AccessGet more information

Cover

More Information
Summary:Histamine release was examined in leukocyte suspensions from patients allergic to grass pollen, mite or cat dander or to bacteria (antigen). When the cells were challenged with specific antigen plus bacteria to which the person was not sensitized, these bacteria were found to potentiate the allergic histamine release. The potentiating effect by bacteria might be due to the bacterial cell wall components, peptidoglycan and teichoic acid, which mimic the effect of bacteria.
ISSN:0065-4299
DOI:10.1007/BF02074661