Lighting up cancer initiation with mutant p53 reporters

In this Tools of the Trade article, Xiwen Tang describes the development of in vivo reporters detecting mutant p53 at the protein level, which enables the visualization of precancerous cells during cancer initiation.

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Bibliographic Details
Published inNature reviews. Cancer Vol. 24; no. 2; p. 95
Main Author Tang, Xiwen
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2024
Subjects
Cell Line, Tumor
Humans
Mutants
Mutation
Neoplasms - genetics
p53 Protein
Tumor Suppressor Protein p53 - genetics
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Summary:In this Tools of the Trade article, Xiwen Tang describes the development of in vivo reporters detecting mutant p53 at the protein level, which enables the visualization of precancerous cells during cancer initiation.
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ISSN:1474-175X
1474-1768
DOI:10.1038/s41568-023-00649-4