Immune response to primary immunization with brucella antigen in mycosis fungoides

The immune response to primary immunization with brucella antigen was studied in 8 patients with mycosis fungoides and 11 controls. The development of as well cellular as humoral hypersensitivity to brucella antigen was followed by in vitro techniques. Both, patients with mycosis fungoides and contr...

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Bibliographic Details
Published inArchiv für dermatologische Forschung Vol. 251; no. 4; p. 311
Main Author Thulin, H
Format Journal Article
LanguageEnglish
Published Germany 01.01.1975
Subjects
Adult
Aged
Antigens, Bacterial
Brucella Vaccine
Cell Migration Inhibition
Female
Hemagglutination Tests
Humans
Hypersensitivity, Delayed
Hypersensitivity, Immediate
Immunity
Immunity, Cellular
Immunization
In Vitro Techniques
Leukocytes - immunology
Male
Middle Aged
Mycosis Fungoides - immunology
Tuberculin Test
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Summary:The immune response to primary immunization with brucella antigen was studied in 8 patients with mycosis fungoides and 11 controls. The development of as well cellular as humoral hypersensitivity to brucella antigen was followed by in vitro techniques. Both, patients with mycosis fungoides and controls were studied for previously acquired delayed hypersensitivity to tuberculin by skin test. The distribution of B and T cells was encountered among the patients. Previously acquired cellular immunity was found equal in the two groups, however, induction of cellular hypersensitivity to brucella antigen was found depressed in mycosis fungoides patients compared with the controls. Also the humoral response to brucella antigen could seem depressed, only one of seven patients with mycosis fungoides had a positive titer, while seven of eleven controls had positive titres following vaccination; but the difference between the two groups was not significant.
ISSN:0003-9187
DOI:10.1007/BF00562235