Central sympathetic dysregulation and immunological abnormalities in a case of progressive facial hemiatrophy (Parry-Romberg disease)

A case of hemifacial atrophy (Parry-Romberg disease) is discussed. Electrophysiological and immunological studies were performed. Electromyography, blink reflex and trigeminal evoked potential abnormalities indicate that the brain stem may be implicated in the aetiology of the disease. Immunological...

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Bibliographic Details
Published inClinical autonomic research Vol. 5; no. 4; p. 199
Main Authors Lonchampt, P, Emile, J, Pélier-Cady, M C, Cadou, B, Barthelaix, A
Format Journal Article
LanguageEnglish
Published Germany 01.09.1995
Subjects
Adolescent
Blinking - physiology
Brain Stem - physiopathology
Electromyography
Evoked Potentials - physiology
Facial Hemiatrophy - immunology
Facial Hemiatrophy - physiopathology
Fluorescent Antibody Technique, Indirect
Humans
Immunoglobulin G - immunology
Male
Neural Pathways - physiopathology
Sympathetic Nervous System - physiopathology
Trigeminal Nerve - physiology
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Summary:A case of hemifacial atrophy (Parry-Romberg disease) is discussed. Electrophysiological and immunological studies were performed. Electromyography, blink reflex and trigeminal evoked potential abnormalities indicate that the brain stem may be implicated in the aetiology of the disease. Immunological evidence favoured this possibility and demonstrated possible involvement of the noradrenergic system. Hyperactivity of the brain stem sympathetic centres, possibly caused by an autoimmune process, may be the primary cause of the cutaneous and subcutaneous atrophy in Parry-Romberg disease.
ISSN:0959-9851
DOI:10.1007/BF01824007