Alpha adrenergic control of growth hormone in adult male rats

Intravenous injection of 0.1 mg/kg clonidine into rats under urethane anaesthesia induced a prompt and long-lasting release of growth hormone, estimated by radioimmunoassay (IRGH), which could be abolished by 0.2 mg/kg phentolamine given into the 3rd ventricle. Injection of 3 mug/kg clonidine into t...

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Bibliographic Details
Published inExperientia Vol. 32; no. 4; p. 529
Main Authors Ruch, W, Jaton, A L, Bucher, B, Marbach, P, Doepfner, W
Format Journal Article
LanguageEnglish
Published Switzerland 15.04.1976
Subjects
Animals
Clonidine - administration & dosage
Clonidine - pharmacology
Growth Hormone - blood
Growth Hormone - metabolism
Injections, Intravenous
Injections, Intraventricular
Male
Phentolamine - pharmacology
Phenylephrine - pharmacology
Pituitary Gland - drug effects
Pituitary Gland, Anterior - drug effects
Pituitary Gland, Anterior - metabolism
Rats
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Summary:Intravenous injection of 0.1 mg/kg clonidine into rats under urethane anaesthesia induced a prompt and long-lasting release of growth hormone, estimated by radioimmunoassay (IRGH), which could be abolished by 0.2 mg/kg phentolamine given into the 3rd ventricle. Injection of 3 mug/kg clonidine into the 3rd ventricle stimulated also the release of IRGH significantly. Intravenous administration of 0.32 mg/kg phenylephrine caused a small and transient release of IRGH only. These results provide evidence that central alpha-adrenergic stimulation resulting in an increased GH secretion is one important mechanism in the regulation of this hormone in the rat.
ISSN:0014-4754
DOI:10.1007/BF01920839