Effects of Isopropyl Unoprostone, Latanoprost, and Prostaglandin E2 on Acute Rise of Aqueous Flare in Pigmented Rabbits

Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E 2 (PGE 2 ) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE 2 , 25 µg/ml, using a glass cylinder, was achieved i...

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Bibliographic Details
Published inOphthalmic research Vol. 34; no. 2; pp. 90 - 93
Main Authors Zhang, Xue-Yun, Hayasaka, Seiji, Hayasaka, Yoriko, Yanagisawa, Shuichiro, Nagaki, Yasunori
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 2002
Subjects
Original Paper
Aqueous flare
Rabbit
Prostaglandin E2
Isopropyl unoprostone
Latanoprost
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Summary:Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E 2 (PGE 2 ) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE 2 , 25 µg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter. Results: Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE 2 . Latanoprost did not induce flare elevation. Conclusion: Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.
ISSN:0030-3747
1423-0259
DOI:10.1159/000048334