Lack of expression of antigens for islet cell antibodies in rat fetal pancreas

It is not clear yet when pancreatic islet cells begin to express antigens for islet cell antibodies (ICA). Therefore, we studied whether human ICA-positive sera, crossreacting with adult rat islet cells, react with fetal and neonatal rat islet cells immunohistologically. The ICA did not react with f...

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Bibliographic Details
Published inJournal of endocrinological investigation Vol. 13; no. 7; p. 601
Main Authors Yamashiro, Y, Taniguchi, H, Baba, S, Taniguchi, T, Kodama, S, Aono, S, Isshiki, G, Jinnouchi, T
Format Journal Article
LanguageEnglish
Published Italy 01.07.1990
Subjects
Aging - immunology
Animals
Antigens - analysis
Antigens - immunology
Autoantibodies - immunology
Blood Proteins - immunology
Cross Reactions - immunology
Fetus - immunology
Pancreas - chemistry
Pancreas - embryology
Pancreas - immunology
Rats
Rats, Inbred Strains
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Summary:It is not clear yet when pancreatic islet cells begin to express antigens for islet cell antibodies (ICA). Therefore, we studied whether human ICA-positive sera, crossreacting with adult rat islet cells, react with fetal and neonatal rat islet cells immunohistologically. The ICA did not react with fetal islet cells. On the other hand, neonatal islet cells over 2-3 weeks of age expressed the reactivities almost similar to those of the adult. It was suspected that pancreatic islet cells started to express their antigens to induce ICA gradually after birth.
ISSN:0391-4097
DOI:10.1007/BF03348638