Immunoscintigraphic localization of inflammatory lesions: pharmacokinetics and estimated absorbed radiation dose in man

• Published in: European journal of nuclear medicine Vol. 13; no. 11; p. 594
• Main Authors: Hasler, P H, Seybold, K, Andres, R Y, Locher, J T, Schubiger, P A
• Format: Journal Article
• Language: English
• Published: Germany 01.02.1988
• Subjects: Animals; Antibodies, Monoclonal - metabolism; Clinical Trials as Topic; Evaluation Studies as Topic; Granulocytes - immunology; Granulocytes - metabolism; Half-Life; Humans; Inflammation - diagnostic imaging; Iodine Radioisotopes - administration & dosage; Iodine Radioisotopes - pharmacokinetics; Iodine Radioisotopes - urine; Mice; Radiation Dosage; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Whole-Body Irradiation
• ISSN: 0340-6997
• DOI: 10.1007/BF02574775

Five patients with inflammatory lesions received anti-granulocytes murine monoclonal antibody (Mabgc) infused over 5 to 15 min at doses between 3.4 and 5.4 mCi 123I (120 micrograms antibody). Clearance of 123I from blood pool closely fits a biexponential mathematical model with the two effective half-lives 0.73 h and 9.3 h. The spontaneous release of 123I was found to be relatively low in the blood pool. The cumulative urinary excretion of the 123I label over 120 h was in the range of 63% of the totally administered dose and is assumed to represent only a low molecular compound or 123I alone as iodide. Analysis of the label in spleen, liver and red marrow showed that the concentration of label in these tissues remains more or less constant over a period of 20 h after infusion. With data of liver, spleen, red marrow and whole body activity over a period of 24 h, an estimated radiation dose was calculated. Compared with 111In labelled leucocytes, especially in spleen, the absorbed dose is lower by a factor of ten per examination.