Comparisons of short-term outcomes between robot-assisted, video-assisted, and open esophagectomy for resectable esophageal cancer after neoadjuvant treatment: a retrospective study

• Published in: Journal of thoracic disease Vol. 16; no. 3; pp. 2019 - 2031
• Main Authors: Wu, Ziheng, Liu, Jiacong, Zhang, Lichen, Tang, Muhu, Shu, Wenbo, van der Wilk, Berend J, Anker, Christopher J, He, Zhehao, Wang, Luming, Lv, Wang, Zhu, Linhai, Hu, Jian
• Format: Journal Article
• Language: English
• Published: China 29.03.2024
• Subjects: Esophageal cancer (EC); video-assisted minimally invasive esophagectomy (VAMIE); robot-assisted esophagectomy (RAE); open esophagectomy (OE); neoadjuvant treatment
• ISSN: 2072-1439; 2077-6624
• DOI: 10.21037/jtd-24-75

Robot-assisted esophagectomy (RAE), video-assisted minimally invasive esophagectomy (VAMIE), and open esophagectomy (OE) all have significant roles in the management of esophageal cancer (EC). Few studies have compared efficacy and safety between RAE, VAMIE, and OE for resectable EC after neoadjuvant treatment. Therefore, this study aimed to explore the short-term outcomes between RAE, VAMIE, and OE for resectable EC after neoadjuvant treatment. Ninety-eight patients were consecutively enrolled who underwent esophagectomy. A retrospective study was performed including 98 consecutive patients treated from January 2021 to August 2022 who received neoadjuvant treatment (including immunochemotherapy and chemoradiotherapy) followed by RAE, VAMIE or OE. Evaluated endpoints in the present study consisted of pathological outcomes, intraoperative and postoperative outcomes, as well as postoperative complications. No significant differences were seen in the operating time, blood loss, length of intensive care unit (ICU) stay, R0 resection, and number of dissected lymph nodes between the three RAE, VAMIE, or OE groups. The achievement rate of right recurrent laryngeal nerve (RLN) lymph node removal (P=0.01) and the total cost (P<0.001) were higher in RAE. The postoperative hospital stay of OE was longer than the other two groups (P<0.05). There were no significant differences in postoperative complications. Compared to VAMIE, no clear benefit exists for RAE in the treatment of resectable EC after neoadjuvant therapy. OE resulted in a longer hospital stay. Although the rate of successful right RLN node removal was higher with RAE, the clinical relevance for this is yet unclear.