Polymorphisms of Ag-stained nucleolar organizer regions in man

Polymorphisms of the NORs as tested by Ag-staining of metaphase G-banded chromosomes were investigated in cultured blood lymphocytes of karyotypically normal individuals from the Moscow population. The study of cell-to-cell variability in the number of Ag-stained NORs carried out on 14 monozygotic t...

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Published inHuman genetics Vol. 60; no. 4; p. 334
Main Authors Zakharov, A F, Davudov, A Z, Benjush, V A, Egolina, N A
Format Journal Article
LanguageEnglish
Published Germany 01.01.1982
Subjects
Azure Stains
Chromosome Banding
Chromosomes, Human, 13-15 - ultrastructure
Chromosomes, Human, 21-22 and Y - ultrastructure
Female
Genetic Variation
Heterozygote
Homozygote
Humans
Lymphocytes - ultrastructure
Male
Metaphase
Nucleolus Organizer Region - analysis
Polymorphism, Genetic
Pregnancy
Silver Nitrate
Twins, Monozygotic
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Summary:Polymorphisms of the NORs as tested by Ag-staining of metaphase G-banded chromosomes were investigated in cultured blood lymphocytes of karyotypically normal individuals from the Moscow population. The study of cell-to-cell variability in the number of Ag-stained NORs carried out on 14 monozygotic twin pairs showed the phenomenon to have some features of real intercellular variation. In 40 unrelated individuals the individual acrocentric chromosomes were compared by the number of Ag-stained NORs, their degree of staining, and their participation in acrocentric association. Chromosome 21 was found to be significantly more active than four others by all the criteria, and chromosome 15 was less active compared with the others by the size of the Ag deposits and the frequency of participation in NOR associations. The frequency distribution of homozygotes and heterozygotes for Ag-stained NORs in the same group of 40 individuals was in accordance with the Hardy-Weinberg law.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00569214