Lupus erythematosus panniculitis: an immunohistochemical study

An immunohistochemical study on a case of lupus erythematosus panniculitis (LEP), without discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE) signs, showed that the cells in skin infiltrates were immunologically committed lymphocytes (OKT4, OKT8, OKT11 and HLA-DR positive cells)...

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Published inClinical rheumatology Vol. 13; no. 4; p. 641
Main Authors Riccieri, V, Sili Scavalli, A, Spadaro, A, Taccari, E, Zoppini, A
Format Journal Article
LanguageEnglish
Published Germany 01.12.1994
Subjects
Disease Progression
Fluorescent Antibody Technique
Humans
Immunohistochemistry
Immunophenotyping
Male
Middle Aged
Panniculitis, Lupus Erythematosus - diagnosis
Panniculitis, Lupus Erythematosus - immunology
Panniculitis, Lupus Erythematosus - pathology
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Summary:An immunohistochemical study on a case of lupus erythematosus panniculitis (LEP), without discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE) signs, showed that the cells in skin infiltrates were immunologically committed lymphocytes (OKT4, OKT8, OKT11 and HLA-DR positive cells) and elements of the monocyte-macrophage lineage (Leu M3 and Leu M5 positive). No immunophenotypically identifiable B-lymphocytes were seen. Immunofluorescent IgG, IgM, C3 and C4 deposits were found in blood vessel walls of the deep dermis. These findings, similar to that described in the skin changes of SLE and DLE, suggest that immunological mechanisms are operative in localized LEP, where the dermal lesions are the only expression of the disease.
ISSN:0770-3198
DOI:10.1007/BF02243010