Behavioral correlates of focal hippocampal x-irradiation in rats

A study presenting findings of focal hippocampal x-irradiation in early infancy and late behavior at two ages was carried out using Long-Evans hooded rats (Rattus norvegicus). Animals from eleven litters received 150-R irradiation treatments for 5 or 15 consecutive days and were then tested in an op...

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Bibliographic Details
Published inExperimental brain research Vol. 24; no. 4; p. 343
Main Authors Wallace, R B, Kaplan, R F, Werboff, J
Format Journal Article
LanguageEnglish
Published Germany 26.02.1976
Subjects
Age Factors
Animals
Avoidance Learning - radiation effects
Behavior, Animal - radiation effects
Hippocampus - cytology
Hippocampus - physiology
Hippocampus - radiation effects
Neurons - radiation effects
Radiation Effects
Rats
X-Rays
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Summary:A study presenting findings of focal hippocampal x-irradiation in early infancy and late behavior at two ages was carried out using Long-Evans hooded rats (Rattus norvegicus). Animals from eleven litters received 150-R irradiation treatments for 5 or 15 consecutive days and were then tested in an open field situation and in a two-way active avoidance apparatus. The results indicated that the behavioral deficits paralleled those seen in animals with classical hippocampal lesions. The results were offered in support of a response suppression model for hippocampal functioning.
ISSN:0014-4819
DOI:10.1007/BF00235002