Cardiovascular Effects of Tricyclic Antidepressants

To the Editor: The Abstract of the article by Veith and his associates (April 22 issue) 1 concludes with the statement "depressed patients with preexisting heart disease can be effectively treated with [tricyclic antidepressants] without an adverse effect on ventricular rhythm or hemodynamic fu...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 307; no. 13; p. 821
Main Author Giardina, E G
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.09.1982
Subjects
Antidepressive Agents, Tricyclic - pharmacology
Cardiovascular System - drug effects
Depression - complications
Drug Interactions
Heart Diseases - complications
Humans
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Summary:To the Editor: The Abstract of the article by Veith and his associates (April 22 issue) 1 concludes with the statement "depressed patients with preexisting heart disease can be effectively treated with [tricyclic antidepressants] without an adverse effect on ventricular rhythm or hemodynamic function." This study reports the relative safety of low-dose imipramine for depressed patients with minimal cardiac impairment. The dose of imipramine (mean ±S.D., 129±57 mg per day) and its corresponding plasma drug concentration (mean, 147± 137 ng per milliliter) were lower than those reported in severely depressed patients. 2 The mean ejection fraction of the subjects who took imipramine . . . No extract is available for articles shorter than 400 words.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198209233071315