Aorto-caval fistula in the rat. An experimental model of heart volume overloading

Abdominal aorto-caval fistula was experimentally induced in rats, and animals were sacrificed 5 days, 1 month, and 6 months later. Cardiac weight almost doubled the normal weight during the first month. Cell length increased to the same extent as the cell width, indicating harmonious growth. Increas...

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Bibliographic Details
Published inBasic research in cardiology Vol. 75; no. 1; p. 105
Main Authors Hatt, P Y, Rakusan, K, Gastineau, P, Laplace, M, Cluzeaud, F
Format Journal Article
LanguageEnglish
Published Germany 01.01.1980
Subjects
Animals
Aortic Diseases - physiopathology
Arteriovenous Fistula - physiopathology
Cardiomegaly - physiopathology
Disease Models, Animal
Female
Heart - anatomy & histology
Mitochondria, Heart
Myocardium - cytology
Organ Size
Permeability
Rats
Venae Cavae - physiopathology
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Summary:Abdominal aorto-caval fistula was experimentally induced in rats, and animals were sacrificed 5 days, 1 month, and 6 months later. Cardiac weight almost doubled the normal weight during the first month. Cell length increased to the same extent as the cell width, indicating harmonious growth. Increase in cell volume, as well as the amount of degenerative changes, were more pronounced in subendocardium than in midwall and subepicardium. Cytological features of active cellular growth was found not only in the early stages (5 days and 1 month) but also 6 months after the operation. This finding is consonant with proteosynthesis stimulation not only in the early period of constitution of hypertrophy but also in the later stages.
ISSN:0300-8428
DOI:10.1007/BF02001401