HLA-DQA1 in autochthonous Basques: description of a genocline for the DQA10201 allele in Europe

A total of 250 autochthonous Basque individuals were tested in the HLA-DQA1 system, and the allele frequency distribution found was significantly different from that of any other European population. The differences centre mainly on the alleles DQA1*0201 and DQA1*0501: for the former the Basques hav...

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Bibliographic Details
Published inInternational journal of legal medicine Vol. 109; no. 4; p. 181
Main Authors Iriondo, M, Manzano, C, de la Rúa, C
Format Journal Article
LanguageEnglish
Published Germany 01.12.1996
Subjects
Adult
Alleles
Cross-Cultural Comparison
Europe
Female
Gene Frequency - genetics
Genetics, Population
Genotype
HLA-DQ alpha-Chains
HLA-DQ Antigens - genetics
Humans
Male
Polymerase Chain Reaction
Europe
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Summary:A total of 250 autochthonous Basque individuals were tested in the HLA-DQA1 system, and the allele frequency distribution found was significantly different from that of any other European population. The differences centre mainly on the alleles DQA1*0201 and DQA1*0501: for the former the Basques have the highest frequency described anywhere in the world (f = 0.210) and for the latter they have the lowest frequency in Europe (f = 0.204). For the allele DQA1*0201 a genocline is also described in Europe with the Basques and Finno-Ugric populations basically at the extremes. The genocline reflects the isolation of the Basque population since prehistoric times, and supports existing linguistic, archaeological and genetic data.
ISSN:0937-9827
DOI:10.1007/BF01225516