Endotoxins release histamine by complement activation and potentiate bacteria-induced histamine release

The histamine-releasing capability of bacterial lipopolysaccharides (LPS) was examined in human leukocyte suspensions. LPS alone did not release histamine, but it was found to enhance the histamine release caused by bacteria in basophils from persons sensitized to these bacteria. In the presence of...

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Bibliographic Details
Published inAgents and actions Vol. 18; no. 1-2; p. 149
Main Authors Norn, S, Jensen, C, Dahl, B T, Stahl Skov, P, Baek, L, Permin, H, Jarløv, J O, Sørensen, H
Format Journal Article
LanguageEnglish
Published Switzerland 01.04.1986
Subjects
Bacteria - immunology
Blood Physiological Phenomena
Complement Activation - drug effects
Elapid Venoms - pharmacology
Endotoxins - pharmacology
Histamine Release - drug effects
Humans
In Vitro Techniques
Lipopolysaccharides - pharmacology
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Summary:The histamine-releasing capability of bacterial lipopolysaccharides (LPS) was examined in human leukocyte suspensions. LPS alone did not release histamine, but it was found to enhance the histamine release caused by bacteria in basophils from persons sensitized to these bacteria. In the presence of serum, LPS was able to release histamine through complement activation. It is speculated that endotoxins reinforce release of histamine caused by bacteria in persons sensitized to these microorganisms, and a direct mediator release via complement activation might play a role in septic conditions.
ISSN:0065-4299
DOI:10.1007/BF01988007