A Unique Antinuclear Antibody Staining Only the Mitotic-Spindle Apparatus

To the Editor: During the performance of screening antinuclear-antibody tests using human epithelial cell substrate (HEp-2) at several institutions, a pattern of staining localized only to the mitotic-spindle apparatus was observed. We have called this pattern (staining of only centrioles and peripo...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 305; no. 12; p. 703
Main Authors McCarty, G A, Valencia, D W, Fritzler, M J, Barada, F A
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 17.09.1981
Subjects
Adult
Aged
Antibodies, Antinuclear - analysis
Cells, Cultured
Female
Humans
Middle Aged
Mitosis
Staining and Labeling
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Summary:To the Editor: During the performance of screening antinuclear-antibody tests using human epithelial cell substrate (HEp-2) at several institutions, a pattern of staining localized only to the mitotic-spindle apparatus was observed. We have called this pattern (staining of only centrioles and peripolar mitotic spindles, and not of cytoplasmic elements throughout the cell cycle) "antibody to the mitotic-spindle apparatus" (anti-MSA). The index serum was from a patient with osteoarthritis; over the past 14 months, 10 other patients have been shown to have anti-MSA, for an estimated frequency of eight in 10,000 screening tests. The 10 patients were women ranging in age . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198109173051223