G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains

The efficiency of signal transduction in cells derives in part from subcellular, in particular plasma membrane, microdomains that organize signaling molecules and signaling complexes. Two related plasma membrane domains that compartmentalize G-protein coupled receptor (GPCR) signaling complexes are...

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Bibliographic Details
Published inHandbook of experimental pharmacology no. 186; p. 167
Main Authors Patel, H H, Murray, F, Insel, P A
Format Journal Article
LanguageEnglish
Published Germany 2008
Subjects
Animals
Caveolae - metabolism
GTP-Binding Proteins - metabolism
Humans
Membrane Lipids - metabolism
Membrane Microdomains - metabolism
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
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Summary:The efficiency of signal transduction in cells derives in part from subcellular, in particular plasma membrane, microdomains that organize signaling molecules and signaling complexes. Two related plasma membrane domains that compartmentalize G-protein coupled receptor (GPCR) signaling complexes are lipid (membrane) rafts, domains that are enriched in certain lipids, including cholesterol and sphingolipids, and caveolae, a subset of lipid rafts that are enriched in the protein caveolin. This review focuses on the properties of lipid rafts and caveolae, the mechanisms by which they localize signaling molecules and the identity of GPCR signaling components that are organized in these domains.
ISSN:0171-2004
DOI:10.1007/978-3-540-72843-6_7