Antiplatelet aggregation principles from Glycosmis citrifolia

• Published in: PTR. Phytotherapy research Vol. 12; no. S1; pp. S77 - S79
• Main Authors: Leu, Yann-Lii, Chan, Yu-Yi, Wu, Tian-Shung, Teng, Che-Ming, Chen, Kuo-Tung
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 1998; Wiley
• Subjects: 2-quinolone; acridone; alkaloids; antiplatelet aggregation; Biological and medical sciences; General pharmacology; Glycosmis citrifolia; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Root; Pharmacognosy; Rutaceae; Bark; Rabbit; Extract; Lagomorpha; In vitro; Biological activity; Antiplatelet agent; Stem; Medicinal plant; Vertebrata; Alkaloid; Platelet; Mammalia; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta; Quinolone derivatives; Structural analysis
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/(SICI)1099-1573(1998)12:1+3.0.CO;2-J

Twelve acridone alkaloids, citracridone‐I (1), atalaphyllidine (2), noracronycine (3), des‐N‐methylnoracronycine (4), 5‐hydroxynor‐acronycine (5), des‐N‐methylacronycine (6), N‐methyl severifoline (7), 5‐hydroxy‐N‐methyl severifoline (8), glycocitrine‐II (9), 3‐O‐methyl‐glycocitrine‐II (10), glycocitrine‐I (11) and pyranofoline (12); one 2‐quinolone alkaloid, 4,8‐dimethoxy‐1‐methyl‐3(3‐methylbut‐2‐enyl)2‐quinolone (13) were isolated and characterized from the stem and root barks of Glycosmis citrifolia. Their structures were determined by spectral analyses. On bioactive evaluation, compounds 1 and 2 almost completely inhibited platelet aggregation induced by arachidonic acid (100 μM), collagen (10 μg/mL) and PAF (2 ng/mL). Compounds 2, 4 and 13 also showed an inhibitory effect on AA and collagen‐induced rabbit platelet aggregation. In the structure and activity relationship of acridone alkaloids, the acridone nucleus bearing a pyranyl moiety is a most important factor for the antiplatelet aggregation activity. © 1998 John Wiley & Sons, Ltd.