A Case of COL1A1-PDGFB Fusion Uterine Sarcoma

COL1A1-PDGFB gene fusion uterine sarcoma is a recently described entity which shows some overlapping features with dermatofibrosarcoma protuberans. To date, only 4 cases have been reported in the literature. Due to its rarity, succinct clinicopathologic characteristics are yet to be established. We...

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Bibliographic Details
Published inInternational journal of gynecological pathology Vol. 42; no. 2; p. 147
Main Authors Hogeboom, Adriana, Bárcena, Carmen, Parrilla-Rubio, Lucía, Revilla, Enrique, Ruano, Yolanda, Gallego-Gutiérrez, Irene, Martínez-López, Mario
Format Journal Article
LanguageEnglish
Published United States 01.03.2023
Subjects
Dermatofibrosarcoma - genetics
Humans
In Situ Hybridization, Fluorescence
Oncogene Proteins, Fusion - genetics
Proto-Oncogene Proteins c-sis - genetics
Skin Neoplasms - pathology
Soft Tissue Neoplasms
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Summary:COL1A1-PDGFB gene fusion uterine sarcoma is a recently described entity which shows some overlapping features with dermatofibrosarcoma protuberans. To date, only 4 cases have been reported in the literature. Due to its rarity, succinct clinicopathologic characteristics are yet to be established. We report a fifth case initially mistaken as a uterine fibroid which histologically proved to be a CD34 + high-grade spindle cell proliferation which on fluorescence in situ hybridization analysis displayed COL1A1-PDGFB gene rearrangement. With this case description we hope to raise awareness and aid in the characterization of this emerging entity.
ISSN:1538-7151
DOI:10.1097/PGP.0000000000000875