Trifluorometyl Phenethyl Mesalazine (TFM) Acts as an Antioxidant and Improves Facial Skin Wrinkles and Whitening

Oxidative stress is a primary contributor to human skin aging, while antioxidants are known to mitigate skin damage related to aging processes. In this study, we investigated the possible action of trifluoromethyl phenethyl mesalazine (TFM), an antioxidizing agent, on skin aging processes, including...

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Bibliographic Details
Published inCosmetics (Basel) Vol. 11; no. 5; p. 158
Main Authors Won, Sojung, Lim, Jane Melissa, Lee, Jin Hwan, Oh, Young J, Shin, Jin-Hee, Gwag, Byoung Joo, Choi, Eui-Ju
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2024
Subjects
Aging
Antioxidants
Care and treatment
Cosmetics
Fibroblasts
Free radicals
Free radicals (Chemistry)
Interleukin 6
Interleukins
Matrix metalloproteinase
Melanin
Melanoma
Metalloproteinase
Oxidative stress
Pigmentation
ROS scavenger
Skin
skin aging
TFM
whitening
Womens health
South Korea
Seoul South Korea
United States > US
Japan
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Summary:Oxidative stress is a primary contributor to human skin aging, while antioxidants are known to mitigate skin damage related to aging processes. In this study, we investigated the possible action of trifluoromethyl phenethyl mesalazine (TFM), an antioxidizing agent, on skin aging processes, including skin wrinkles and pigmentation. Our data revealed that TFM exerted a strong free radical scavenging capability and notably inhibited melanin production. Moreover, TFM downregulated the UV-induced production of matrix metalloproteinase-1 and interleukin-6 in cultured human skin fibroblasts. Furthermore, in a clinical study with 24 women, TFM significantly reduced skin wrinkles and improved skin brightness compared to a placebo. These findings highlight the previously unrecognized effects of TFM on skin health by mitigating skin aging processes associated with oxidative damage.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics11050158