Synthesis and antitumour activity of new daunorubicin and adriamycin analogues

A new synthetic procedure for the preparation of daunorubicin and adriamycin analogues bearing different substituents on ring D, has been developed. The new compounds display outstanding efficacy against experimental tumours of mice.

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Bibliographic Details
Published inExperientia Vol. 34; no. 10; p. 1255
Main Authors Arcamone, F, Bernardi, L, Patelli, B, Giardino, P, Di Marco, A, Casazza, A M, Soranzo, C, Pratesi, G
Format Journal Article
LanguageEnglish
Published Switzerland 15.10.1978
Subjects
Animals
Cell Survival - drug effects
Daunorubicin - analogs & derivatives
Daunorubicin - chemical synthesis
Daunorubicin - therapeutic use
Doxorubicin - analogs & derivatives
Doxorubicin - chemical synthesis
Doxorubicin - therapeutic use
HeLa Cells - drug effects
Leukemia, Experimental - drug therapy
Structure-Activity Relationship
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Summary:A new synthetic procedure for the preparation of daunorubicin and adriamycin analogues bearing different substituents on ring D, has been developed. The new compounds display outstanding efficacy against experimental tumours of mice.
ISSN:0014-4754
DOI:10.1007/BF01981401