Two new ent-kaurane glucosides from the fruits of Xanthium strumarium subsp. sibiricum

The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named 2-O-(6-O-isocaleryl-β-D-glucopyranosyl) atractyligenin (1) and 2-O-(2-O-isovaleryl-β-D-glucopyranosyl) atractyligenin (2), together with one known compound. The...

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Published inNatural product research Vol. 36; no. 7; pp. 1820 - 1826
Main Authors Yao, Tie, Wang, Jiaxin, Cao, Shijie, Liu, Da, Duan, Jingshi, Yu, Yaqin, Kang, Ning, Qiu, Feng
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.04.2022
Subjects
Diterpenes, Kaurane - chemistry
ent-kaurane glucosides
Fruit
Glucosides - chemistry
Glucosides - pharmacology
Humans
structural elucidation
Xanthium - chemistry
Xanthium strumarium
structural elucidation
ent-kaurane glucosides
Xanthium strumarium
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Abstract The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named 2-O-(6-O-isocaleryl-β-D-glucopyranosyl) atractyligenin (1) and 2-O-(2-O-isovaleryl-β-D-glucopyranosyl) atractyligenin (2), together with one known compound. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction and electronic circular dichroism data. All compounds and their aglycone were evaluated for their anti-proliferative activities in vitro against three human cancer cell lines.
AbstractList The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named 2-O-(6-O-isocaleryl-β-D-glucopyranosyl) atractyligenin (1) and 2-O-(2-O-isovaleryl-β-D-glucopyranosyl) atractyligenin (2), together with one known compound. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction and electronic circular dichroism data. All compounds and their aglycone were evaluated for their anti-proliferative activities in vitro against three human cancer cell lines.
The chemical investigation of the fruits of (Asteraceae) led to the isolation of two new -kauranoid glucosides named 2- -(6- -isocaleryl- -D-glucopyranosyl) atractyligenin ( ) and 2- -(2- -isovaleryl- -D-glucopyranosyl) atractyligenin ( ), together with one known compound. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction and electronic circular dichroism data. All compounds and their aglycone were evaluated for their anti-proliferative activities against three human cancer cell lines.
Author Liu, Da
Cao, Shijie
Kang, Ning
Wang, Jiaxin
Yu, Yaqin
Qiu, Feng
Yao, Tie
Duan, Jingshi
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CitedBy_id crossref_primary_10_1016_j_bioorg_2024_107527
crossref_primary_10_1007_s11101_024_09966_4
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Snippet The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named...
The chemical investigation of the fruits of (Asteraceae) led to the isolation of two new -kauranoid glucosides named 2- -(6- -isocaleryl- -D-glucopyranosyl)...
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SubjectTerms Diterpenes, Kaurane - chemistry
ent-kaurane glucosides
Fruit
Glucosides - chemistry
Glucosides - pharmacology
Humans
structural elucidation
Xanthium - chemistry
Xanthium strumarium
Title Two new ent-kaurane glucosides from the fruits of Xanthium strumarium subsp. sibiricum
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Volume 36
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