Two new ent-kaurane glucosides from the fruits of Xanthium strumarium subsp. sibiricum

The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named 2-O-(6-O-isocaleryl-β-D-glucopyranosyl) atractyligenin (1) and 2-O-(2-O-isovaleryl-β-D-glucopyranosyl) atractyligenin (2), together with one known compound. The...

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Published inNatural product research Vol. 36; no. 7; pp. 1820 - 1826
Main Authors Yao, Tie, Wang, Jiaxin, Cao, Shijie, Liu, Da, Duan, Jingshi, Yu, Yaqin, Kang, Ning, Qiu, Feng
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.04.2022
Subjects
Diterpenes, Kaurane - chemistry
ent-kaurane glucosides
Fruit
Glucosides - chemistry
Glucosides - pharmacology
Humans
structural elucidation
Xanthium - chemistry
Xanthium strumarium
structural elucidation
ent-kaurane glucosides
Xanthium strumarium
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Summary:The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named 2-O-(6-O-isocaleryl-β-D-glucopyranosyl) atractyligenin (1) and 2-O-(2-O-isovaleryl-β-D-glucopyranosyl) atractyligenin (2), together with one known compound. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction and electronic circular dichroism data. All compounds and their aglycone were evaluated for their anti-proliferative activities in vitro against three human cancer cell lines.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1819268