Immunohistochemical localization of somatostatin in the human hypothalamus

In order to identify clearly the nervous structures containing somatostatin in the human hypothalamus, an immunohistochemical localization of this neurohormone was performed at light-microscopic level. Using a antiserum specific to somatostatin and the unlabeled antibody peroxidase-antiperoxidase te...

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Bibliographic Details
Published inCell and tissue research Vol. 184; no. 4; p. 491
Main Authors Désy, L, Pelletier, G
Format Journal Article
LanguageEnglish
Published Germany 23.11.1977
Subjects
Adult
Aged
Female
Humans
Hypothalamus - analysis
Hypothalamus - anatomy & histology
Hypothalamus, Anterior - analysis
Immunoenzyme Techniques
Male
Mammillary Bodies - analysis
Middle Aged
Neurons - analysis
Pineal Gland - analysis
Somatostatin - isolation & purification
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Summary:In order to identify clearly the nervous structures containing somatostatin in the human hypothalamus, an immunohistochemical localization of this neurohormone was performed at light-microscopic level. Using a antiserum specific to somatostatin and the unlabeled antibody peroxidase-antiperoxidase technique, we have found somatostatin in neurons with cell bodies in an area in the anterior hypothalamus corresponding to the infundibular nucleus. Somatostatin-containing fibers were also detected in the neurovascular zone of the pituitary stalk, suggesting that somatostatin is released in that region to reach the capillaries in the pituitary portal plexus. A large bundle of somatostatin fibers extending from the anterior part of the paraventricular nucleus up to the posterior portion of the mammillary bodies has also been detected. The role of these fibers still remains to be clarified.
ISSN:0302-766X
DOI:10.1007/BF00220972