Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral delta-oxoacid derivatives

Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 10; pp. 1327 - 1329
Main Authors Amat, M, Bassas, O, Pericas, MA, Pasto, M, Bosch, J
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.03.2005
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
PIPERIDINES
QUINOLIZIDINE ALKALOIDS
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Summary:Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.
ISSN:1359-7345
1364-548X
DOI:10.1039/b413937b