Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral delta-oxoacid derivatives
Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.
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Published in | Chemical communications (Cambridge, England) no. 10; pp. 1327 - 1329 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
14.03.2005
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Subjects | |
Online Access | Get more information |
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Summary: | Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/b413937b |