Use of ATR-FTIR spectroscopy to study the diffusion of ethanol through glycerogelatin films

The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow recep...

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Bibliographic Details
Published inPharmaceutical research Vol. 12; no. 4; p. 572
Main Authors Tralhão, A M, Watkinson, A C, Brain, K R, Hadgraft, J, Armstrong, N A
Format Journal Article
LanguageEnglish
Published United States 01.04.1995
Subjects
Diffusion
Ethanol - chemistry
Gelatin
Spectroscopy, Fourier Transform Infrared
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Summary:The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow receptor phase diffusion cell show good agreement in terms of lag time assessed diffusion coefficients. ATR-FTIR spectroscopy revealed time-dependent changes in the composition of the glycerogelatin film during the diffusional process. It was also demonstrated that the concurrent assessment of both diffusant penetration and film composition is feasible.
ISSN:0724-8741
DOI:10.1023/A:1016262215192