The influence of culture medium composition on the incidence of chromosomal breakage
In patients with chromosomal instability and healthy subjects, significant differences were observed in the chromosomal breakage incidence in simultaneous lymphocyte cultures set up with TC medium 199, Eagle's Minimum Essential Medium, or RPMI, or RPMI 1629. The importance of the choice of cult...
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| Published in | Human genetics Vol. 50; no. 3; p. 277 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
01.09.1979
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| Subjects | |
| Online Access | Get more information |
| ISSN | 0340-6717 |
| DOI | 10.1007/BF00399393 |
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| Abstract | In patients with chromosomal instability and healthy subjects, significant differences were observed in the chromosomal breakage incidence in simultaneous lymphocyte cultures set up with TC medium 199, Eagle's Minimum Essential Medium, or RPMI, or RPMI 1629. The importance of the choice of culture medium for mutagenicity testing and studies of so-called spontaneous breakage is shown. Cultures incubated with TC Medium 199 showed the highest chromosomal breakage incidence. |
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| AbstractList | In patients with chromosomal instability and healthy subjects, significant differences were observed in the chromosomal breakage incidence in simultaneous lymphocyte cultures set up with TC medium 199, Eagle's Minimum Essential Medium, or RPMI, or RPMI 1629. The importance of the choice of culture medium for mutagenicity testing and studies of so-called spontaneous breakage is shown. Cultures incubated with TC Medium 199 showed the highest chromosomal breakage incidence. |
| Author | Emerit, I Keck, M |
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| SubjectTerms | Ascorbic Acid Cells, Cultured Chromosome Aberrations - pathology Chromosome Disorders Chromosomes, Human - ultrastructure Culture Media Cysteine Humans Lymphocytes - physiology Polysorbates |
| Title | The influence of culture medium composition on the incidence of chromosomal breakage |
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