Spectrum of Common α-Globin Deletion Mutations in the Southern Region of Vietnam

• Published in: Hemoglobin Vol. 40; no. 3; pp. 206 - 207
• Main Authors: Bui Thi Kim, Ly, Phu Chi, Dung, Hoang Thanh, Chi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.05.2016
• Subjects: alpha-Globins - genetics; alpha-Thalassemia - genetics; Humans; Molecular Epidemiology; Mutation; Sequence Deletion - genetics; Vietnam; Vietnam - epidemiology; α-Globin genes; α-thalassemia (α-thal); α-Globin genes; Vietnam; α-thalassemia (α-thal)
• ISSN: 0363-0269; 1532-432X
• DOI: 10.3109/03630269.2016.1166126

The common deletion mutations of α-globin genes in the Vietnamese population is not well known. Here we report the presence of five deletional mutations of Southeast Asia in the southern region of Vietnam. The - - SEA (NG_000006.1: g.26264_45564del19301) mutation is the most common type of deletion (87.35%), followed by the -α 3.7 (rightward) (NG_000006.1: g.34164_37967del3804) deletion (9.64%), -α 4.2 (leftward) (AF221717) deletion (2.41%) and - - THAI (NG_000006.1: g.10664_44164del33501) (0.6%) mutation in this region. The - - FIL (NG_000006.1: g.11684_43534del31581) mutation was not detected in this study. This result provided a view of the distribution of common α-globin gene mutations in Vietnam and could serve as a baseline for further investigations into these genetic defects.