Mesenchymal stem cell-derived exosomes as cell free nanotherapeutics and nanocarriers

Many strategies for regenerating the damaged tissues or degenerating cells are employed in regenerative medicine. Stem cell technology is a modern strategy of the recent approaches, particularly the use of mesenchymal stem cells (MCSs). The ability of MSCs to differentiate as well as their character...

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Published inNanomedicine Vol. 61; p. 102769
Main Authors Abid, Ali Imran, Conzatti, Guillaume, Toti, Florence, Anton, Nicolas, Vandamme, Thierry
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2024
Subjects
Extracellular vesicles
MSCs
Nano-carriers
Nanotherapeutics
Extracellular vesicles
Nanotherapeutics
MSCs
Nano-carriers
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Summary:Many strategies for regenerating the damaged tissues or degenerating cells are employed in regenerative medicine. Stem cell technology is a modern strategy of the recent approaches, particularly the use of mesenchymal stem cells (MCSs). The ability of MSCs to differentiate as well as their characteristic behaviour as paracrine effector has established them as key elements in tissue repair. Recently, extracellular vesicles (EVs) shed by MSCs have emerged as a promising cell free therapy. This comprehensive review encompasses MSCs-derived exosomes and their therapeutic potential as nanotherapeutics. We also discuss their potency as drug delivery nano-carriers in comparison with liposomes. A better knowledge of EVs behaviour in vivo and of their mechanism of action are key to determine parameters of an optimal formulation in pilot studies and to establish industrial processes.
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ISSN:1549-9634
1549-9642
1549-9642
DOI:10.1016/j.nano.2024.102769