The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability

(1)H and (19)F NMR, and UV thermal melting studies have established that the stability of d(TCCCCC) is enhanced by the inclusion of a single 2'-fluorine-modified deoxycytidine residue; the results support the notion of the importance of sugar-sugar contacts in stabilising i-motifs in general an...

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Published inChemical communications (Cambridge, England) no. 30; pp. 3567 - 3569
Main Authors Fenna, Clare P, Wilkinson, Victoria J, Arnold, John R P, Cosstick, Richard, Fisher, Julie
Format Journal Article
LanguageEnglish
Published England 01.01.2008
Subjects
Base Sequence
DNA - chemistry
DNA - genetics
DNA - metabolism
Fluorine - chemistry
Magnetic Resonance Spectroscopy
Nucleic Acid Conformation
Nucleic Acid Denaturation
Solvents - chemistry
Transition Temperature
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Summary:(1)H and (19)F NMR, and UV thermal melting studies have established that the stability of d(TCCCCC) is enhanced by the inclusion of a single 2'-fluorine-modified deoxycytidine residue; the results support the notion of the importance of sugar-sugar contacts in stabilising i-motifs in general and reveal that solvation is the cause of the instability of RNA equivalents.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/b804833a