Batch and continuous flow mechanochemical synthesis of organic compounds including APIs

Mechanochemistry is becoming an enabling technology for the synthesis of organic and inorganic compounds as well as for the synthesis of polymers as it underlines sustainability in a significant manner. Continuous mechanochemical synthesis further adds value to the approach through consistency, smal...

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Published inReaction chemistry & engineering Vol. 9; no. 1; pp. 1 - 25
Main Authors Atapalkar, Ranjit S, Kulkarni, Amol A
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 20.12.2023
Subjects
Agrochemicals
Chemical synthesis
Continuous flow
Inorganic compounds
Organic compounds
Polymers
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Summary:Mechanochemistry is becoming an enabling technology for the synthesis of organic and inorganic compounds as well as for the synthesis of polymers as it underlines sustainability in a significant manner. Continuous mechanochemical synthesis further adds value to the approach through consistency, smaller footprint, and better energy efficiency. This review gives an indepth view of the present status of this subject along with critical engineering aspects that one needs to measure and monitor as eventually synthesis needs to be transformed into a process. The examples covered herein include the synthesis of organic compounds, viz. , APIs, agrochemical intermediates, catalysts, and polymers. In the end, we also discuss the safety aspects of mechanochemical synthesis and recommendations for exploring this field further. Mechanochemistry is becoming an enabling technology for the synthesis of organic and inorganic compounds as well as for the synthesis of polymers as it underlines sustainability in a significant manner.
Bibliography:Mr. Ranjit Shabu Atapalkar received his B.Sc. (Shivaji University, Kolhapur) and M.Sc. (Organic Chemistry) from PAH Solapur University, Solapur, India with first class in 2014. He cleared the CSIR-NET exam with (AIR) All India Rank 62 in 2016 and was awarded a Junior as well as Senior Research Fellowship by the CSIR, New Delhi. He is currently pursuing his Ph.D. at CSIR-National Chemical Laboratory, Pune. His research is mainly focused on solid phase flow synthesis, mechanochemistry, flow synthesis of large organic molecules and continuous anionic polymerization and multi-step Synthesis of Active Pharmaceuticals Ingredients.
Dr. Amol A. Kulkarni is a Chief Scientist in the Chemical Engineering & Process Development Division at the CSIR-National Chemical Laboratory (NCL), Pune, India. He is a chemical engineer by training and did Ph.D. in chemical engineering (2003) from the Institute of Chemical Technology ICT- Mumbai. He did his Post-Doctorate at the Max Planck Institute-Magdeburg (Germany) (2004) and at Massachusetts Institute of Technology, USA (2010). He works in the area of design and development of continuous flow reactors and explores their applications for continuous syntheses of pharmaceutical intermediates, dyes, agrochemicals, perfumery chemicals and nanomaterials. He has developed several scalable continuous processes for important organic compounds and inorganic functional materials including many solvent free synthesis protocols. He also works on experimental and numerical analysis of multiphase fluid dynamics in presence of diffusion and reaction.
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ISSN:2058-9883
2058-9883
DOI:10.1039/d2re00521b